Syllabus For 2000
Reading: Mechanisms of Microbial Disease, 3rd Ed., Schaechter, Engleberg, Eisenstein, Medoff
Lecture: Monday, Wednesday, and Friday, at 11:00 am
Laboratory: Tuesday Morning, 9:00-12:00
Laboratory Manual: compiled by the instructor

Host-Parasite Interactions: the course

We will examine the attributes of an animal host which will permit its survival in a sea of microorganisms and parasites. This resistance to disease is due to a complex interaction of cells and chemicals that make up the tissues and fluids of the host. Dispite these elaborate defenses, most mammals are still susceptible to infectious organisms which are a part of the host's own normal flora, the normal flora of other animals, or a part of the environment. Bacteria, viruses, protozoa, and other disease agents possess a variety of techniques for overwhelming the physical and chemical barriers that protect the host, thus allowing the onset of disease.

In this course you will examine the balance between the host's defenses and the microorganism's virulence factors which can shift; resulting in periods where the animal experiences good health on one hand and diseased states on the other hand when a particular organism has been able to tip the balance in its favor. We will learn about the innate and acquired forms of immunity that are typically found in higher animals and then we will look at how selected bacteria, fungi, viruses, and parasites can cause diseases in humans.

In order to be able to respond to a particular disease agent, we must know some of its characteristics. It will be important to know how it is transmitted to the host as well as where it usually enters the body. You will need to discover how it escapes from a diseased individual and also if there are specific factors associated with the agent which might be neutralized resulting in a cure or the prevention of disease.

The text will serve as a resource for uncovering some of the relationships that exist between host and parasite but we will not depend only on it as a source of information. During the semester, I will assign mini projects to be done by using library and Internet resources, thus we will be able to obtain current information about a specific topic.

I will have you research a particular topic of your choice (with some limitations) and have you give a presentation to the class. This project will allow you to dig deeper into an area of medical microbiology that is not possible by limiting ourselves to class lectures as a means for learning.




There will be four, one hour exams @ 100 pts each: 400pts
Quizzes will be:                                                             100pts
Laboratory reports:                                                     100pts
Laboratory practical:                                                     50pts

The laboratory reports will be done in a scientific format with a title page, introduction, materials and methods, results, and discussion. (Laboratory information will be included on the one hour exams.)


Date                                                         Topic                                                                 Reading
Feb. 2                             Establishment of Infectious Diseases                                      Ch. 1&2
Feb. 4                             Normal Flora of the human host                                               Ch. 2

Feb. 7                             Constitutive Defenses of the host                                            Ch. 6
Feb. 9                             Inflammation and phagocytosis                                                Ch. 6
Feb. 11                           Induced (acquired immunity):
                                       Examples, biological characteristics                                        Ch. 7
Feb. 14                           Immunoglobulins                                                                       Ch. 7
Feb. 16                           Cellular aspects of the immune response                                Ch. 7
Feb. 18                           Immune injury: hypersensitivities and deficiencies                Ch. 7

Feb. 21                           Microbial virulence factors                                                      Ch. 8&9
Feb. 23                           Introduction to bacterial infections, Staphylococcal
                                       infections                                                                                   Ch. 10&11
Feb. 25                           Staph and strep infections                                                        Ch. 11&12

Feb. 28                           Streptococcal infections                                                           Ch. 12
Mar. 1                            Pneumococci                                                                             Ch. 13
Mar. 3                            Gram negative cocci: Neisseria species                                 Ch. 14
                                       EXAM ON MAR. 2&3

Mar. 6                           Bacteroides infections and an introduction to
                                       Enterobacteriaceae                                                                   Ch. 15&16
Mar. 8                           Watery diarrhea and infections due to E. coli 0157:H7          Ch. 16&17
Mar. 10                         Opportunistic Gram negative bacteria (Pseudomonas
                                       and others)                                                                                 Ch. 18

Mar. 13                         Clostridia: obligate anaerobes                                                  Ch. 20
Mar. 15                         Whooping cough, Legionella, and Heilicobacter pylori           Ch. 19, 21 & 22
                                                                                                                                                                                                                                                                                                        Mar. 17                         Tuberculosis                                                                               Ch. 23

Mar. 20
Mar. 22                          Spring Break
Mar. 24

Mar. 27                          Syphilis and other diseases caused by spirochetes                 Ch. 24&25
Mar. 29                          Chlamydia                                                                                  Ch. 27
Mar. 31                          Rickettsioses and Mycoplasmic infections                              Ch. 28&29
                                        Second Examination

Apr. 3                             Biology of viruses                                                                      Ch. 31
Apr. 5                             Picornaviruses (Polio, Rhinoviruses)                                        Ch. 32
Apr. 7                             Comparison of Myxoviruses and Paramyxoviruses                Ch. 34

Apr. 10                           Myxoviruses and Paramyxoviruses                                         Ch. 36
Apr. 12                           AIDS                                                                                           Ch. 37 & 68
Apr. 14                           Adenovirus infections                                                                Ch. 39

Apr. 17                           Warts: seed warts and genital warts                                         Ch. 40
Apr. 19                           Herpesvirus family                                                                     Ch. 41
                                       Third Examination Apr. 19&20
Apr. 21                           Good Friday

Apr. 24                            Easter Monday
Apr. 26                            Viral Hepatitis                                                                           Ch. 42
Apr. 28                            Combating viral Infections                                                        Ch. 43

May 3                              Immunization                                                                             Ch. 44
May 5                              Principles of  epidemiology                                                       Ch. 56
May 7                              The compromised patient (immune deficiencies)                     Ch. 67

May 8                              Student presentations
May 10                            Student presentations
May 12                            Student presentations

May 17
May 19                             FINAL EXAMINATION WEEK
May 21


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